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Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin
Chikashi Obuse, Jun-ichi Nakayama
Biochimica et Biophysica Acta (BBA) - General Subjects Vol. 1869 No. 6 p. 130790-130790 2025年5月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
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Interaction mapping between nucleoporins in the fission yeast Schizosaccharomyces pombe using mass-spectrometry
Haruhiko Asakawa, Koji Nagao, Tatsuo Fukagawa, Chikashi Obuse, Yasushi Hiraoka, Tokuko Haraguchi
The Journal of Biochemistry Vol. 177 No. 4 p. 273-286 2024年12月27日 研究論文（学術雑誌）
出版者・発行元：Oxford University Press (OUP)
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Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46
Yutaka Mahana, Mariko Ariyoshi, Ryu-Suke Nozawa, Sachiko Shibata, Koji Nagao, Chikashi Obuse, Masahiro Shirakawa
Structure Vol. 32 No. 3 p. 304-315.e5 2024年3月 研究論文（学術雑誌）
出版者・発行元：Elsevier BV
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Functional domains of nuclear long noncoding RNAs: Insights into gene regulation and intracellular architecture
Chikashi Obuse, Tetsuro Hirose
Current Opinion in Cell Biology 2023年12月 研究論文（学術雑誌）
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Replication dynamics identifies the folding principles of the inactive X chromosome
Rawin Poonperm, Saya Ichihara, Hisashi Miura, Akie Tanigawa, Koji Nagao, Chikashi Obuse, Takashi Sado, Ichiro Hiratani
Nature Structural & Molecular Biology Vol. 30 No. 8 p. 1224-1237 2023年8月10日 研究論文（学術雑誌）
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Dominant-negative variants in CBX1 cause a neurodevelopmental disorder.
Yukiko Kuroda, Aiko Iwata-Otsubo, Kerith-Rae Dias, Suzanna E L Temple, Koji Nagao, Lachlan De Hayr, Ying Zhu, Shin-Ya Isobe, Gohei Nishibuchi, Sarah K Fiordaliso, Yuki Fujita, Alyssa L Rippert, Samuel W Baker, Marco L Leung, Daniel C Koboldt, Adele Harman, Beth A Keena, Izumi Kazama, Gopinath Musuwadi Subramanian, Kandamurugu Manickam, Betsy Schmalz, Maeson Latsko, Elaine H Zackai, Matt Edwards, Carey-Anne Evans, Matthew C Dulik, Michael F Buckley, Toshihide Yamashita, W Timothy O'Brien, Robert J Harvey, Chikashi Obuse, Tony Roscioli, Kosuke Izumi
Genetics in medicine : official journal of the American College of Medical Genetics Vol. 25 No. 7 p. 100861-100861 2023年7月 研究論文（学術雑誌）
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Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.
Yasuhiro Hirano, Yasuha Kinugasa, Yoshino Kubota, Chikashi Obuse, Tokuko Haraguchi, Yasushi Hiraoka
Journal of biochemistry 2023年2月17日 研究論文（学術雑誌）
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Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
Osamu Masui, Catherine Corbel, Koji Nagao, Takaho A Endo, Fuyuko Kezuka, Patricia Diabangouaya, Manabu Nakayama, Mami Kumon, Yoko Koseki, Chikashi Obuse, Haruhiko Koseki, Edith Heard
Nature cell biology Vol. 25 No. 1 p. 134-144 2023年1月 研究論文（学術雑誌）
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RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi
Communications Biology Vol. 5 No. 1 2022年12月28日 研究論文（学術雑誌）
出版者・発行元：Springer Science and Business Media LLC
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SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice
Saya Ichihara, Koji Nagao, Takehisa Sakaguchi, Chikashi Obuse, Takashi Sado
Development 2022年8月1日 研究論文（学術雑誌）
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Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry.
Yoko Hayashi-Takanaka, Yuichiro Hayashi, Yasuhiro Hirano, Atsuko Miyawaki-Kuwakado, Yasuyuki Ohkawa, Chikashi Obuse, Hiroshi Kimura, Tokuko Haraguchi, Yasushi Hiraoka
Nucleic acids research Vol. 49 No. 21 p. 12152-12166 2021年12月2日 研究論文（学術雑誌）
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Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.
Shin-Ya Isobe, Shin-Ichiro Hiraga, Koji Nagao, Hiroyuki Sasanuma, Anne D Donaldson, Chikashi Obuse
Cell reports Vol. 36 No. 2 p. 109383-109383 2021年7月13日 研究論文（学術雑誌）
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Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing.
Hisashi Miura, Saori Takahashi, Takahiro Shibata, Koji Nagao, Chikashi Obuse, Katsuzumi Okumura, Masato Ogata, Ichiro Hiratani, Shin-Ichiro Takebayashi
Nature protocols Vol. 15 No. 12 p. 4058-4100 2020年12月 研究論文（学術雑誌）
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Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections.
Seiichi Sato, Kai Li, Nozomi Sakurai, Mei Hashizume, Sunanda Baidya, Hirotaka Nonaka, Koki Noguchi, Kozo Ishikawa, Chikashi Obuse, Akinori Takaoka
Cellular immunology Vol. 356 p. 104188-104188 2020年10月 研究論文（学術雑誌）
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Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency.
Kenichi Kinjo, Keisuke Nagasaki, Koji Muroya, Erina Suzuki, Keisuke Ishiwata, Kazuhiko Nakabayashi, Atsushi Hattori, Koji Nagao, Ryu-Suke Nozawa, Chikashi Obuse, Kenji Miyado, Tsutomu Ogata, Maki Fukami, Mami Miyado
Scientific reports Vol. 10 No. 1 p. 10985-10985 2020年7月3日 研究論文（学術雑誌）
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Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy.
Kohei Hamanaka, Darina Šikrová, Satomi Mitsuhashi, Hiroki Masuda, Yukari Sekiguchi, Atsuhiko Sugiyama, Kazumoto Shibuya, Richard J L F Lemmers, Remko Goossens, Megumu Ogawa, Koji Nagao, Chikashi Obuse, Satoru Noguchi, Yukiko K Hayashi, Satoshi Kuwabara, Judit Balog, Ichizo Nishino, Silvère M van der Maarel
Neurology Vol. 94 No. 23 2020年6月9日 研究論文（学術雑誌）
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Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab.
Mariko Ogawa-Momohara, Yoshinao Muro, Katsunobu Goto, Chikashi Obuse, Minoru Satoh, Michihiro Kono, Masashi Akiyama
The Journal of dermatology Vol. 47 No. 6 2020年6月
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KDM2A-dependent reduction of rRNA transcription on glucose starvation requires HP1 in cells, including triple-negative breast cancer cells.
Okamoto K, Tanaka Y, Ogasawara S, Obuse C, Nakayama JI, Yano H, Tsuneoka M
Oncotarget Vol. 10 No. 46 p. 4743-4760 2019年7月 研究論文（学術雑誌）
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Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast
Haruhiko Asakawa, Gregory P. Copenhaver, Tomoko Kojidani, Hui-Ju Yang, Chizuru Ohtsuki, Hiroko Osakada, Atsushi Matsuda, Masaaki Iwamoto, Yuji Chikashige, Koji Nagao, Chikashi Obuse, Yasushi Hiraoka, Tokuko Haraguchi
PLOS Genetics Vol. 15 No. 6 2019年6月6日 研究論文（学術雑誌）
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Genome-wide stability of the DNA replication program in single mammalian cells.
Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Katsuzumi Okumura, Masato Ogata, Chikashi Obuse, Shin-Ichiro Takebayashi, Ichiro Hiratani
Nature genetics Vol. 51 No. 3 p. 529-540 2019年3月 研究論文（学術雑誌）
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Publisher Correction: Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.
Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, Takasugi M, Watanabe S, Kanemaki MT, Obuse C, Hara E
Nature Communications Vol. 9 No. 1 2018年10月 研究論文（学術雑誌）
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Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice.
Sakakibara Y, Nagao K, Blewitt M, Sasaki H, Obuse C, Sado T
Development (Cambridge, England) Vol. 145 No. 18 2018年9月
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Functional characterization of lysosomal interaction of Akt with VRK2
Noriyuki Hirata, Futoshi Suizu, Mami Matsuda-Lennikov, Tsutomu Tanaka, Tatsuma Edamura, Satoko Ishigaki, Thoria Donia, Pathrapol Lithanatudom, Chikashi Obuse, Toshihiko Iwanaga, Masayuki Noguchi
Oncogene p. 1-20 2018年6月5日 研究論文（学術雑誌）
出版者・発行元：Nature Publishing Group
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Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1
Riki Terui, Koji Nagao, Yoshitaka Kawasoe, Kanae Taki, Torahiko L. Higashi, Seiji Tanaka, Takuro Nakagawa, Chikashi Obuse, Hisao Masukata, Tatsuro S. Takahashi
Genes and Development Vol. 32 No. 11-12 p. 806-821 2018年6月1日 研究論文（学術雑誌）
出版者・発行元：Cold Spring Harbor Laboratory Press
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Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast
Yasuhiro Hirano, Yasuha Kinugasa, Haruhiko Asakawa, Yuji Chikashige, Chikashi Obuse, Tokuko Haraguchi, Yasushi Hiraoka
Genes to Cells Vol. 23 No. 3 p. 122-135 2018年3月2日 研究論文（学術雑誌）
出版者・発行元：Wiley-Blackwell
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分裂酵母に特異的な核膜孔複合体の構造
淺川 東彦, 糀谷 知子, Yang Hui-Ju, 小坂田 裕子, 大槻 千鶴, 長尾 恒治, 小布施 力史, 平岡 泰, 原口 徳子
生命科学系学会合同年次大会 Vol. 2017年度 p. [4LT18-0283)] 2017年12月
出版者・発行元：生命科学系学会合同年次大会運営事務局
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Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi
Takuya Kajitani, Hiroaki Kato, Yuji Chikashige, Chihiro Tsutsumi, Yasushi Hiraoka, Hiroshi Kimura, Yasuyuki Ohkawa, Chikashi Obuse, Damien Hermand, Yota Murakami
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 114 No. 52 p. E11208-E11217 2017年12月 研究論文（学術雑誌）
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Defects in dosage compensation impact global gene regulation in the mouse trophoblast
Yuka Sakata, Koji Nagao, Yuko Hoki, Hiroyuki Sasaki, Chikashi Obuse, Takashi Sado
DEVELOPMENT Vol. 144 No. 15 p. 2784-2797 2017年8月 研究論文（学術雑誌）
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Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM2
Sugako Ogushi, Kazuo Yamagata, Chikashi Obuse, Keiko Furuta, Teruhiko Wakayama, Martin M. Matzuk, Mitinori Saitou
JOURNAL OF CELL SCIENCE Vol. 130 No. 14 p. 2416-2429 2017年7月 研究論文（学術雑誌）
-
Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair
Shin-Ya Isobe, Koji Nagao, Naohito Nozaki, Hiroshi Kimura, Chikashi Obuse
CELL REPORTS Vol. 20 No. 2 p. 297-307 2017年7月 研究論文（学術雑誌）
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Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in the ciliate Tetrahymena
Masaaki Iwamoto, Hiroko Osakada, Chie Mori, Yasuhiro Fukuda, Koji Nagao, Chikashi Obuse, Yasushi Hiraoka, Tokuko Haraguchi
JOURNAL OF CELL SCIENCE Vol. 130 No. 10 p. 1822-1834 2017年5月 研究論文（学術雑誌）
-
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T. Kanemaki, Chikashi Obuse, Eiji Hara
NATURE COMMUNICATIONS Vol. 8 2017年5月 研究論文（学術雑誌）
-
Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation.
Luna Yamaguchi, Atsuya Nishiyama, Toshinori Misaki, Yoshikazu Johmura, Jun Ueda, Kyohei Arita, Koji Nagao, Chikashi Obuse, Makoto Nakanishi
Scientific reports Vol. 7 No. 1 p. 55-55 2017年3月3日 研究論文（学術雑誌）
-
Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation
Shin-ichiro Hiraga, Tony Ly, Javier Garzon, Zuzana Horejsi, Yoshi-nobu Ohkubo, Akinori Endo, Chikashi Obuse, Simon J. Boulton, Angus I. Lamond, Anne D. Donaldson
EMBO REPORTS Vol. 18 No. 3 p. 403-419 2017年3月 研究論文（学術雑誌）
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BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation
Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano, Atsushi Shibata
CELL REPORTS Vol. 18 No. 2 p. 520-532 2017年1月 研究論文（学術雑誌）
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The dataset of proteins specifically interacted with activated TICAM-1
Kenji Funami, Misako Matsumoto, Hiroyuki Oshiumi, Chikashi Obuse, Tsukasa Seya
Data in Brief Vol. 8 p. 697-699 2016年9月1日 研究論文（学術雑誌）
出版者・発行元：Elsevier Inc.
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Corrigendum to "Clinical, muscle pathological, and genetic features of Japanese facioscapulohumeral muscular dystrophy 2 (FSHD2) patients with SMCHD1 mutations": [Neuromuscular Disorders 26/4-5 (2016) 300-308].
Kohei Hamanaka, Kanako Goto, Mami Arai, Koji Nagao, Chikashi Obuse, Satoru Noguchi, Yukiko K Hayashi, Satomi Mitsuhashi, Ichizo Nishino
Neuromuscular disorders : NMD Vol. 26 No. 7 p. 472-472 2016年7月
-
Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast
Shota Suzuki, Hiroaki Kato, Yutaka Suzuki, Yuji Chikashige, Yasushi Hiraoka, Hiroshi Kimura, Koji Nagao, Chikashi Obuse, Shinya Takahata, Yota Murakami
NUCLEIC ACIDS RESEARCH Vol. 44 No. 9 p. 4147-4162 2016年5月 研究論文（学術雑誌）
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14-3-3-zeta participates in TLR3-mediated TICAM-1 signal-platform formation
Kenji Funami, Misako Matsumoto, Chikashi Obuse, Tsukasa Seya
MOLECULAR IMMUNOLOGY Vol. 73 p. 60-68 2016年5月 研究論文（学術雑誌）
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Clinical, muscle pathological, and genetic features of Japanese facioscapulohumeral muscular dystrophy 2 (FSHD2) patients with SMCHD1 mutations
Kohei Hamanaka, Kanako Goto, Mami Arai, Koji Nagao, Chikashi Obuse, Satoru Noguchi, Yukiko K. Hayashi, Satomi Mitsuhashi, Ichizo Nishino
NEUROMUSCULAR DISORDERS Vol. 26 No. 4-5 p. 300-308 2016年4月 研究論文（学術雑誌）
-
Histone H4 lysine 20 acetylation is associated with gene repression in human cells
Jun-Ya Kaimori, Kazumitsu Maehara, Yoko Hayashi-Takanaka, Akihito Harada, Masafumi Fukuda, Satoko Yamamoto, Naotsugu Ichimaru, Takashi Umehara, Shigeyuki Yokoyama, Ryo Matsuda, Tsuyoshi Ikura, Koji Nagao, Chikashi Obuse, Naohito Nozaki, Shiro Takahara, Toshifumi Takao, Yasuyuki Ohkawa, Hiroshi Kimura, Yoshitaka Isaka
SCIENTIFIC REPORTS Vol. 6 2016年4月 研究論文（学術雑誌）
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新規核局在化シグナル受容体importin α8の機能解析
宮本 洋一, 盛山 哲嗣, 木本 千裕, 辻井 聡, 五十嵐 芳暢, 小布施 力史, 岡 正啓, 米田 悦啓
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 88回・38回 p. [1T23-14(1P0045)] 2015年12月
出版者・発行元：(公社)日本生化学会
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核内輸送因子Importin αとヒストン結合タンパクRBBP4の非典型的結合とその生理的意義
辻井 聡, 宮本 洋一, 盛山 哲嗣, 土屋 裕子, 小布施 力史, 水口 賢司, 岡 正啓, 米田 悦啓
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 88回・38回 p. [1P0151]-[1P0151] 2015年12月
出版者・発行元：(公社)日本生化学会
-
Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies
Yoko Hayashi-Takanaka, Kazumitsu Maehara, Akihito Harada, Takashi Umehara, Shigeyuki Yokoyama, Chikashi Obuse, Yasuyuki Ohkawa, Naohito Nozaki, Hiroshi Kimura
CHROMOSOME RESEARCH Vol. 23 No. 4 p. 753-766 2015年12月 研究論文（学術雑誌）
-
Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence
Akira Tsujii, Yoichi Miyamoto, Tetsuji Moriyama, Yuko Tsuchiya, Chikashi Obuse, Kenji Mizuguchi, Masahiro Oka, Yoshihiro Yoneda
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 290 No. 49 p. 29375-29388 2015年12月 研究論文（学術雑誌）
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LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1
Megumi Tatematsu, Kenji Funami, Noriko Ishii, Tsukasa Seya, Chikashi Obuse, Misako Matsumoto
JOURNAL OF IMMUNOLOGY Vol. 195 No. 10 p. 4933-4942 2015年11月 研究論文（学術雑誌）
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Functional characterization of importin α8 as a classical nuclear localization signal receptor.
Kimoto C, Moriyama T, Tsujii A, Igarashi Y, Obuse C, Miyamoto Y, Oka M, Yoneda Y
Biochimica et biophysica acta Vol. 1853 No. 10 p. 2676-2683 2015年10月 研究論文（学術雑誌）
-
Functional characterization of importin α8 as a classical nuclear localization signal receptor.
Kimoto C, Moriyama T, Tsujii A, Igarashi Y, Obuse C, Miyamoto Y, Oka M, Yoneda Y
Biochimica et biophysica acta Vol. 1853 No. 10 Pt A p. 2676-2683 2015年10月
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HJURP is involved in the expansion of centromeric chromatin
Marinela Perpelescu, Tetsuya Hori, Atsushi Toyoda, Sadahiko Misu, Norikazu Monma, Kazuho Ikeo, Chikashi Obuse, Asao Fujiyama, Tatsuo Fukagawa
MOLECULAR BIOLOGY OF THE CELL Vol. 26 No. 15 p. 2742-2754 2015年8月 研究論文（学術雑誌）
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Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box
Tetsuji Moriyama, Percival Sangel, Hiroki Yamaguchi, Chikashi Obuse, Yoichi Miyamoto, Masahiro Oka, Yoshihiro Yoneda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 462 No. 3 p. 201-207 2015年7月 研究論文（学術雑誌）
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An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions
Nao Saito, Hongjiang Qiao, Teruki Yanagi, Satoru Shinkuma, Keiko Nishimura, Asuka Suto, Yasuyuki Fujita, Shotaro Suzuki, Toshifumi Nomura, Hideki Nakamura, Koji Nagao, Chikashi Obuse, Hiroshi Shimizu, Riichiro Abe
SCIENCE TRANSLATIONAL MEDICINE Vol. 6 No. 245 2014年7月 研究論文（学術雑誌）
-
A novel method for purification of the endogenously expressed fission yeast Set2 complex
Shota Suzuki, Koji Nagao, Chikashi Obuse, Yota Murakami, Shinya Takahata
PROTEIN EXPRESSION AND PURIFICATION Vol. 97 p. 44-49 2014年5月 研究論文（学術雑誌）
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2SDA-05 HP1をとおして見えてきたヘテロクロマチンの構造と機能(2SDA 生命現象の基本に迫る動的クロマチン構造・機能研究の最前線,新学術領域研究「動的クロマチン構造と機能」共催,シンポジウム,第52回日本生物物理学会年会(2014年度))
小布施 力史
生物物理 Vol. 54 No. 1 2014年
出版者・発行元：一般社団法人 日本生物物理学会
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CxxC-ZF Domain Is Needed for KDM2A to Demethylate Histone in rDNA Promoter in Response to Starvation
Yuji Tanaka, Toshiyuki Umata, Kengo Okamoto, Chikashi Obuse, Makoto Tsuneoka
CELL STRUCTURE AND FUNCTION Vol. 39 No. 1 p. 79-92 2014年 研究論文（学術雑誌）
-
Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA
Shoko Hoshina, Kei Yura, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga, Haruka Kadoma, Ayaka Nakatsuka, Tomoko Kunichika, Chikashi Obuse, Shou Waga
Journal of Biological Chemistry Vol. 288 No. 42 p. 30161-30171 2013年10月18日 研究論文（学術雑誌）
-
Genetically encoded system to track histone modification in vivo
Sato Y, Mukai M, Ueda J, Muraki M, Stasevich T J, Horikoshi N, Kujirai T, Kita H, Kimura T, Hira S, Okada Y, Hayashi-Takanaka Y, Obuse C, Kurumizaka H, Kawahara A, Yamagata K, Nozaki N, Kimura H
Sci Rep No. 3 2013年8月
-
Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription
Akihisa Osakabe, Hiroaki Tachiwana, Motoki Takaku, Tetsuya Hori, Chikashi Obuse, Hiroshi Kimura, Tatsuo Fukagawa, Hitoshi Kurumizaka
JOURNAL OF CELL SCIENCE Vol. 126 No. 6 p. 1323-1332 2013年3月 研究論文（学術雑誌）
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Genetically encoded system to track histone modification in vivo.
Yuko Sato, Masanori Mukai, Jun Ueda, Michiko Muraki, Timothy J Stasevich, Naoki Horikoshi, Tomoya Kujirai, Hiroaki Kita, Taisuke Kimura, Seiji Hira, Yasushi Okada, Yoko Hayashi-Takanaka, Chikashi Obuse, Hitoshi Kurumizaka, Atsuo Kawahara, Kazuo Yamagata, Naohito Nozaki, Hiroshi Kimura
Scientific reports Vol. 3 p. 2436-2436 2013年 研究論文（学術雑誌）
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Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway
Ryu-Suke Nozawa, Koji Nagao, Ken-Taro Igami, Sachiko Shibata, Natsuko Shirai, Naohito Nozaki, Takashi Sado, Hiroshi Kimura, Chikashi Obuse
Nature Structural and Molecular Biology Vol. 20 No. 5 p. 566-573 2013年 研究論文（学術雑誌）
出版者・発行元：Nature Publishing Group
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A co-localization model of paired ChIP-seq data using a large ENCODE data set enables comparison of multiple samples
Kazumitsu Maehara, Jun Odawara, Akihito Harada, Tomohiko Yoshimi, Koji Nagao, Chikashi Obuse, Koichi Akashi, Taro Tachibana, Toshio Sakata, Yasuyuki Ohkawa
NUCLEIC ACIDS RESEARCH Vol. 41 No. 1 p. 54-62 2013年1月 研究論文（学術雑誌）
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新規ヒストン相互作用因子hsSpt2の核小体クロマチンダイナミクスにおける機能
越阪部 晃永, 立和名 博昭, 高久 誉大, 堀 哲也, 小布施 力史, 木村 宏, 深川 竜郎, 胡桃坂 仁志
日本生化学会大会プログラム・講演要旨集 Vol. 85回 p. 3T22-01 2012年12月
出版者・発行元：(公社)日本生化学会
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Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo
Ryuta Arai, Masumi Tsuda, Takuya Watanabe, Toyoyuki Ose, Chikashi Obuse, Katsumi Maenaka, Akio Minami, Yusuke Ohba
EUROPEAN JOURNAL OF CANCER Vol. 48 No. 15 p. 2417-2430 2012年10月 研究論文（学術雑誌）
-
Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair
Koichi Sato, Masamichi Ishiai, Kazue Toda, Satoshi Furukoshi, Akihisa Osakabe, Hiroaki Tachiwana, Yoshimasa Takizawa, Wataru Kagawa, Hiroyuki Kitao, Naoshi Dohmae, Chikashi Obuse, Hiroshi Kimura, Minoru Takata, Hitoshi Kurumizaka
EMBO JOURNAL Vol. 31 No. 17 p. 3524-3536 2012年8月 研究論文（学術雑誌）
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Epstein-Barr Nuclear Antigen 1 (EBNA1)-dependent Recruitment of Origin Recognition Complex (Orc) on oriP of Epstein-Barr Virus with Purified Proteins STIMULATION BY Cdc6 THROUGH ITS DIRECT INTERACTION WITH EBNA1
Kenji Moriyama, Naoko Yoshizawa-Sugata, Chikashi Obuse, Toshiki Tsurimoto, Hisao Masai
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 287 No. 28 p. 23977-23994 2012年7月 研究論文（学術雑誌）
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An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation.
Yuki Nakaoka, Tomohiro Miki, Ryuta Fujioka, Ryota Uehara, Akiko Tomioka, Chikashi Obuse, Minoru Kubo, Yuji Hiwatashi, Gohta Goshima
The Plant cell Vol. 24 No. 4 p. 1478-93 2012年4月
出版者・発行元：4
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A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules
Makoto Iimori, Kanako Ozaki, Yuji Chikashige, Toshiyuki Habu, Yasushi Hiraoka, Takahisa Maki, Ikuko Hayashi, Chikashi Obuse, Tomohiro Matsumoto
EXPERIMENTAL CELL RESEARCH Vol. 318 No. 3 p. 262-275 2012年2月 研究論文（学術雑誌）
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タンパク質複合体の構成因子を同定するための試料調製法
長尾 恒治, 野澤 竜介, 小布施 力史
日本プロテオーム学会大会要旨集 Vol. 2012 p. 78-78 2012年
出版者・発行元：日本プロテオーム学会（日本ヒトプロテオーム機構）
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CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast
Masayoshi Fukuura, Koji Nagao, Chikashi Obuse, Tatsuro S. Takahashi, Takuro Nakagawa, Hisao Masukata
MOLECULAR BIOLOGY OF THE CELL Vol. 22 No. 14 p. 2620-2633 2011年7月 研究論文（学術雑誌）
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SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver
Atsushi Takahashi, Ryouhei Tsutsumi, Ippei Kikuchi, Chikashi Obuse, Yasuhiro Saito, Azadeh Seidl, Robert Karisch, Minerva Fernandez, Taewoo Cho, Naomi Ohnishi, Orit Rozenblatt-Rosen, Matthew Meyerson, Benjamin G. Neel, Masanori Hatakeyama
MOLECULAR CELL Vol. 43 No. 1 p. 45-56 2011年7月 研究論文（学術雑誌）
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Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast
Tamon Tanaka, Toshiko Umemori, Shizuko Endo, Sachiko Muramatsu, Masato Kanemaki, Yoichiro Kamimura, Chikashi Obuse, Hiroyuki Araki
EMBO JOURNAL Vol. 30 No. 10 p. 2019-2030 2011年5月 研究論文（学術雑誌）
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The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II
Satoshi Abe, Kota Nagasaka, Youko Hirayama, Hiroko Kozuka-Hata, Masaaki Oyama, Yutaka Aoyagi, Chikashi Obuse, Toru Hirota
GENES & DEVELOPMENT Vol. 25 No. 8 p. 863-874 2011年4月 研究論文（学術雑誌）
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Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation
Ayako Watanabe, Megumi Tatematsu, Kazuko Saeki, Sachiko Shibata, Hiroaki Shime, Akihiko Yoshimura, Chikashi Obuse, Tsukasa Seya, Misako Matsumoto
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 286 No. 12 p. 10702-10711 2011年3月 研究論文（学術雑誌）
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プロテオミクスを用いたエピジェネティクス形成制御ネットワークの解明
小布施 力史
日本プロテオーム学会大会要旨集 Vol. 2011 p. 59-59 2011年
出版者・発行元：日本プロテオーム学会（日本ヒトプロテオーム機構）
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細胞核内のクロマチン空間配置におけるアクチン関連タンパク質Arp6の機能解析
北村 大志, 大渕 恵理, 田辺 秀之, 小布施 力史, 堀 哲也, 深川 竜郎, 原田 昌彦
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 83回・33回 p. 3P-0719 2010年12月
出版者・発行元：(公社)日本生化学会
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Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1
Yukimasa Takeishi, Eiji Ohashi, Kaori Ogawa, Hisao Masai, Chikashi Obuse, Toshiki Tsurimoto
GENES TO CELLS Vol. 15 No. 7 p. 761-771 2010年7月 研究論文（学術雑誌）
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Human POGZ modulates dissociation of HP1 alpha from mitotic chromosome arms through Aurora B activation
Ryu-Suke Nozawa, Koji Nagao, Hiro-Taka Masuda, Osamu Iwasaki, Toru Hirota, Naohito Nozaki, Hiroshi Kimura, Chikashi Obuse
NATURE CELL BIOLOGY Vol. 12 No. 7 p. 719-U212 2010年7月 研究論文（学術雑誌）
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Characterization of the interaction of influenza virus NS1 with Akt.
Matsuda M, Suizu F, Hirata N, Miyazaki T, Obuse C, Noguchi M
Biochemical and biophysical research communications Vol. 395 No. 3 p. 312-317 2010年5月
出版者・発行元：3
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Nucleosome Formation Activity of Human Somatic Nuclear Autoantigenic Sperm Protein (sNASP)
Akihisa Osakabe, Hiroaki Tachiwana, Takaaki Matsunaga, Tatsuya Shiga, Ryu-Suke Nozawa, Chikashi Obuse, Hitoshi Kurumizaka
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 285 No. 16 p. 11913-11921 2010年4月 研究論文（学術雑誌）
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Cul8/Rtt101 Forms a Variety of Protein Complexes That Regulate DNA Damage Response and Transcriptional Silencing
Satoru Mimura, Tsuyoshi Yamaguchi, Satoru Ishii, Emiko Noro, Tomoya Katsura, Chikashi Obuse, Takumi Kamura
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 285 No. 13 p. 9858-9867 2010年3月 研究論文（学術雑誌）
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Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes
Tomomi Kiyomitsu, Osamu Iwasaki, Chikashi Obuse, Mitsuhiro Yanagida
JOURNAL OF CELL BIOLOGY Vol. 188 No. 6 p. 791-807 2010年3月 研究論文（学術雑誌）
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The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt
Futoshi Suizu, Yosuke Hiramuki, Fumihiko Okumura, Mami Matsuda, Akiko J. Okumura, Noriyuki Hirata, Masumi Narita, Takashi Kohno, Jun Yokota, Miyuki Bohgaki, Chikashi Obuse, Shigetsugu Hatakeyama, Toshiyuki Obata, Masayuki Noguchi
DEVELOPMENTAL CELL Vol. 17 No. 6 p. 800-810 2009年12月 研究論文（学術雑誌）
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Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor
Yuichiro Hanyu, Kumiko K. Imai, Yosuke Kawasaki, Takahiro Nakamura, Yukinobu Nakaseko, Koji Nagao, Aya Kokubu, Masahiro Ebe, Asuka Fujisawa, Takeshi Hayashi, Chikashi Obuse, Mitsuhiro Yanagida
GENES TO CELLS Vol. 14 No. 5 p. 539-554 2009年5月 研究論文（学術雑誌）
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Active establishment of centromeric CENP-A chromatin by RSF complex
Marinela Perpelescu, Naohito Nozaki, Chikashi Obuse, Hua Yang, Kinya Yoda
JOURNAL OF CELL BIOLOGY Vol. 185 No. 3 p. 397-407 2009年5月 研究論文（学術雑誌）
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The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.
Ryota Uehara, Ryu-suke Nozawa, Akiko Tomioka, Sabine Petry, Ronald D Vale, Chikashi Obuse, Gohta Goshima
Proceedings of the National Academy of Sciences of the United States of America Vol. 106 No. 17 p. 6998-7003 2009年4月28日
出版者・発行元：17
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Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres
Yasutoshi Tatsumi, Kai Ezura, Kazumasa Yoshida, Takashi Yugawa, Mako Narisawa-Saito, Tohru Kiyono, Satoshi Ohta, Chikashi Obuse, Masatoshi Fujita
GENES TO CELLS Vol. 13 No. 10 p. 1045-1059 2008年10月 研究論文（学術雑誌）
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Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin
Yuu Kimata, Akihisa Matsuyama, Koji Nagao, Kanji Furuya, Chikashi Obuse, Minoru Yoshida, Mitsuhiro Yanagida
JOURNAL OF CELL SCIENCE Vol. 121 No. 7 p. 1107-1118 2008年4月 研究論文（学術雑誌）
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Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1
Tomomi Kiyomitsu, Chikashi Obuse, Mitsuhiro Yanagida
DEVELOPMENTAL CELL Vol. 13 No. 5 p. 663-676 2007年11月 研究論文（学術雑誌）
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alpha-klotho as a regulator of calcium homeostasis
Akihiro Imura, Yoshihito Tsuji, Miyahiko Murata, Ryota Maeda, Koji Kubota, Akiko Iwano, Chikashi Obuse, Kazuya Togashi, Makoto Tominaga, Naoko Kita, Ken-ichi Tomiyama, Junko Iijima, Yoko Nabeshima, Makio Fujioka, Ryo Asato, Shinzo Tanaka, Ken Kojima, Juichi Ito, Kazuhiko Nozaki, Nobuo Hashimoto, Tetsufumi Ito, Takeshi Nishio, Takashi Uchiyama, Toshihiko Fujimori, Yo-ichi Nabeshima
SCIENCE Vol. 316 No. 5831 p. 1615-1618 2007年6月 研究論文（学術雑誌）
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Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
Iraj Saadat, Hideaki Higashi, Chikashi Obuse, Mayumi Umeda, Naoko Murata-Kamiya, Yasuhiro Saito, Huaisheng Lu, Naomi Ohnishi, Takeshi Azuma, Atsushi Suzuki, Shigeo Ohno, Masanori Hatakeyama
NATURE Vol. 447 No. 7142 p. 330-U8 2007年5月 研究論文（学術雑誌）
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Priming of centromere for CENP-A recruitment by human hMis18 alpha, hMis18 beta, and M18BP1
Yohta Fujita, Takeshi Hayashi, Tomomi Kiyomitsu, Yusuke Toyoda, Aya Kokubu, Chikashi Obuse, Mitsuhiro Yanagida
DEVELOPMENTAL CELL Vol. 12 No. 1 p. 17-30 2007年1月 研究論文（学術雑誌）
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Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
H Izuta, M Ikeno, N Suzuki, T Tomonaga, N Nozaki, C Obuse, Y Kisu, N Goshima, F Nomura, N Nomura, K Yoda
GENES TO CELLS Vol. 11 No. 6 p. 673-684 2006年6月 研究論文（学術雑誌）
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Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
H Nishitani, N Sugimoto, Roukos, V, Y Nakanishi, M Saijo, C Obuse, T Tsurimoto, KI Nakayama, K Nakayama, M Fujita, Z Lygerou, T Nishimoto
EMBO JOURNAL Vol. 25 No. 5 p. 1126-1136 2006年3月 研究論文（学術雑誌）
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A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1
C Obuse, O Iwasaki, T Kiyomitsu, G Goshima, Y Toyoda, M Yanagida
NATURE CELL BIOLOGY Vol. 6 No. 11 p. 1135-U37 2004年11月 研究論文（学術雑誌）
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The reconstituted human Chl12-RFC complex functions as a second PCNA loader
Y Shiomi, A Shinozaki, K Sugimoto, J Usukura, C Obuse, T Tsurimoto
GENES TO CELLS Vol. 9 No. 4 p. 279-290 2004年4月 研究論文（学術雑誌）
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Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase
C Obuse, H Yang, N Nozaki, SH Goto, T Okazaki, K Yoda
GENES TO CELLS Vol. 9 No. 2 p. 105-120 2004年2月 研究論文（学術雑誌）
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The ORC1 cycle in human cells - II. Dynamic changes in the human ORC complex during the cell cycle
S Ohta, Y Tatsumi, M Fujita, T Tsurimoto, C Obuse
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278 No. 42 p. 41535-41540 2003年10月 研究論文（学術雑誌）
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The ORC1 cycle in human cells - I. Cell cycle-regulated oscillation of human ORC1
Y Tatsumi, S Ohta, H Kimura, T Tsurimoto, C Obuse
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278 No. 42 p. 41528-41534 2003年10月 研究論文（学術雑誌）
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The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore
G Goshima, O Iwasaki, C Obuse, M Yanagida
EMBO JOURNAL Vol. 22 No. 11 p. 2752-2763 2003年6月 研究論文（学術雑誌）
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A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates - Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein
S Ohta, Y Shiomi, K Sugimoto, C Obuse, T Tsurimoto
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277 No. 43 p. 40362-40367 2002年10月 研究論文（学術雑誌）
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PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA
T Iida, Suetake, I, S Tajima, H Morioka, S Ohta, C Obuse, T Tsurimoto
GENES TO CELLS Vol. 7 No. 10 p. 997-1007 2002年10月 研究論文（学術雑誌）
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Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC
Y Shiomi, A Shinozaki, D Nakada, K Sugimoto, J Usukura, C Obuse, T Tsurimoto
GENES TO CELLS Vol. 7 No. 8 p. 861-868 2002年8月 研究論文（学術雑誌）
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Scheduled conversion of replication complex architecture at replication origins of Saccharomyces cerevisiae during the cell cycle
R Tadokoro, M Fujita, H Miura, K Shirahige, H Yoshikawa, T Tsurimoto, C Obuse
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277 No. 18 p. 15881-15889 2002年5月 研究論文（学術雑誌）
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The human homologue of fission yeast cdc27, p66, is a component of active human DNA polymerase delta
K Shikata, S Ohta, K Yamada, C Obuse, H Yoshikawa, T Tsurimoto
JOURNAL OF BIOCHEMISTRY Vol. 129 No. 5 p. 699-708 2001年5月 研究論文（学術雑誌）
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ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C
Y Shiomi, J Usukura, Y Masamura, K Takeyasu, Y Nakayama, C Obuse, H Yoshikawa, T Tsurimoto
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 97 No. 26 p. 14127-14132 2000年12月 研究論文（学術雑誌）
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Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures
Y Tatsumi, T Tsurimoto, K Shirahige, H Yoshikawa, C Obuse
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 8 p. 5904-5910 2000年2月 研究論文（学術雑誌）
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Cell cycle dependent topological changes of chromosomal replication origins in Saccharomyces cerevisiae
M Fujita, Y Hori, K Shirahige, T Tsurimoto, H Yoshikawa, C Obuse
GENES TO CELLS Vol. 3 No. 11 p. 737-749 1998年11月 研究論文（学術雑誌）
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Regulation of DNA-replication origins during cell-cycle progression
K Shirahige, Y Hori, K Shiraishi, M Yamashita, K Takahashi, C Obuse, T Tsurimoto, H Yoshikawa
NATURE Vol. 395 No. 6702 p. 618-621 1998年10月 研究論文（学術雑誌）
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Interaction of transcription factor YY1 with a replication-enhancing element, REE1, in an autonomously replicating human chromosome fragment
C Obuse, T Okazaki, H Masukata
NUCLEIC ACIDS RESEARCH Vol. 26 No. 10 p. 2392-2397 1998年5月 研究論文（学術雑誌）
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The efficiency and timing of initiation of replication of multiple replicons of Saccharomyces cerevisiae chromosome VI
M Yamashita, Y Hori, T Shinomiya, C Obuse, T Tsurimoto, H Yoshikawa, K Shirahige
GENES TO CELLS Vol. 2 No. 11 p. 655-665 1997年11月 研究論文（学術雑誌）
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Characterization of a novel CDC gene (ORC1) partly homologous to CDC6 of Saccharomyces cerevisiae
Y Hori, K Shirahige, C Obuse, T Tsurimoto, H Yoshikawa
MOLECULAR BIOLOGY OF THE CELL Vol. 7 No. 3 p. 409-418 1996年3月 研究論文（学術雑誌）
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A replication-enhancing element with transcriptional silencer activity in autonomously replicating human chromosomal fragments
C Obuse, Y Okuno, T Okazaki, H Masukata
MOLECULAR BIOLOGY OF THE CELL Vol. 7 No. 1 p. 43-55 1996年1月 研究論文（学術雑誌）
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AUTONOMOUS REPLICATION OF HUMAN CHROMOSOMAL DNA FRAGMENTS IN HUMAN-CELLS
H MASUKATA, H SATOH, C OBUSE, T OKAZAKI
MOLECULAR BIOLOGY OF THE CELL Vol. 4 No. 11 p. 1121-1132 1993年11月 研究論文（学術雑誌）
